Bowman Lab
Department of Biochemistry
Jacobs School of Medicine & Biomedical Sciences
University at Buffalo
Publications
Campomizzi, CS, Snell, ME, Mikolajek, H, Sandy, J, Sanchez-Weatherby, J, Budziszewski, GR, Russi, S, Cohen, AE, Hough, MA, Bowman, SEJ. Does crossing the pond affect crystal quality? 2025, Posted on BioRxiv and under review.
Budziszewski, GR, Lynch, ML, Snell, ME, Monteiro, DCF, Bowman, SEJ. Burkholderia pseudomallei rubrerythrin promiscuously binds metals in a structurally pre-formed bimetallic binding site. 2025, Posted on BioRxiv and under review.
Budziszewski, GR, Stojanoff, V, Bowman, SEJ. Preparing for successful protein crystallization experiments. Acta Cryst F 2025, F81, 272-280.
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Bowman, SEJ, Byrnes, J, Russi, S, Zimanyi, C. Preparing research samples for safe arrival at Centers and Facilities: recipes for successful experiments. Acta Cryst F 2024, F80,165-172.
Acehan, D, Spoth, KA, Budziszewski, GR, Snell, ME, Campomizzi, CS, Lynch, ML, Bowman, SEJ. Reaching the potential of electron diffraction. Cell Reports Physical Science. 2024, 5 (6) 102007.
Aragon, M, Bowman, SEJ, Chen, J, de la Cruz, MJ, Decato, D, Eng, E, Flatt, K, Gulati, S, Li, Y, Lomba, C, Mercado, Waterman, D, Wei, A, Zimanyi, C. Applying 3DED and microED workflows towards the next frontiers. Acta Cryst C Special Issue on Advances in Electron Diffraction for Structural Characterization. 2024, C80, 179-189.
Budziszewski, GR, Snell, ME, Wright, TR, Lynch, ML, Bowman, SEJ. High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography. J. Vis. Exp. 2023, (193), e65211.
Lynch, ML, Snell, ME, Potter, SA, Snell, EH, Bowman, SEJ. 20 years of crystal hits: progress and promise in ultrahigh-throughput crystallization screening. Acta Cryst. 2023, D79, 198-205.
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Miller, RD, Iinishi, A, Modaresi, SM, Yoo, B-K, Curtis, TD, Lariviere, PJ, Liang, L, Son, S, Nicolau, S, Bargabos, R, Morrissette, M, Gates, MF, Pitt, N, Jakob, RP, Rath, P, Maier, T, Mayutin, AG, Kaiser, JT, Niles, S, Karavas, B, Ghiglieri, M, Bowman, SEJ, Rees, DC, Hiller, S, Lewis, K. Computational identification of a systemic antibiotic for gram-negative bacteria. Nat Microbiol. 2022, 7(10):1661-1672.
Chattopadhyay, S, Mukherjee, M, Kandemir, B, Bowman, SEJ, Bren, KL, Dey, A. Contributions to Cytochrome c Inner- and Outer-Sphere Reorganization Energy. Chemical Science, 2021, 12: 11894-913.
Lynch, ML, Snell, EH, Bowman, SEJ. Structural biology in the time of COVID-19: perspectives on methods and milestones. IUCrJ 2021; 8, 3, 335-341.
Holleman, ET, Duguid, E, Keefe, LJ, Bowman, SEJ. Polo: an open-source graphical user interface for crystallization screening. Journal of Applied Crystallography, 2021; 54(2):673-679.
Westerman, EL, Bowman, SEJ, Davidson, B, Davis, MC, Larson, ER, Sanford, C. Deploying Big Data to Crack the Genotype to Phenotype Code. Integrative and Comparative Biology, 2020; 60(2):385-396.
Lynch, ML, Dudek, MF, Bowman, SEJ. A Searchable Database of Crystallization Cocktails in the PDB: Analyzing the Chemical Condition Space. Patterns 2020; 1(4), 100024.
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Bowman, SEJ, Backman, LRF, Bjork, RE, Andorfer, MC, Yori, S, Caruso, A, Stultz, CM, Drennan, CL. Solution structure and biochemical characterization of a spare part protein that restores activity to an oxygen-damaged glycyl radical enzyme. Journal of Biological Inorganic Chemistry (2019). 24:817.
Nakashige, TG, Bowman, SEJ, Zygiel, EM, Drennan, CL, Nolan, EM. Biophysical Examination of the Calcium-Modulated Nickel-Binding Properties of Human Calprotectin Reveals Conformational Change in the EF-Hand Domains and His3Asp Site. Biochemistry, 2018; 57(28):4155-4164.
Bowman, SEJ*, Bridwell-Rabb, J*, Drennan, CL. Metalloprotein crystallography: More than a structure. Acc Chem Res. 2016 Apr 19;49(4):695-702. *denotes co-first author publication.
ACS Editors’ Choice Article
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Gagnon, DM, Brophy, MB, Bowman, SEJ, Stich, TA, Drennan, CL, Britt, RD, Nolan, EM. Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis. J Am Chem Soc. 2015 Mar 4;137(8):3004-16.
Galinato, MGI, Bowman, SEJ, Kleingardner, JG, Martin, S, Zhao, JY, Sturhahn, W, Alp, EE, Bren, KL, Lehnert, L. Effects of protein structure on iron-polypeptide vibrational dynamic coupling in cytochrome c. Biochemistry. 2015 Feb 3;54(4):1064-76.
Kleingardner, JG, Bowman, SEJ, Bren, KL The influence of heme ruffling on porphyrin spin densities in cytochromes c probed by core heme carbon NMR. Inorg Chem. 2013 Nov 18;52(22):12933-46.
Galinato, MGI, Kleingardner, JG, Bowman, SEJ, Alp, EE, Zhao, J, Bren, KL, Lehnert, N. Heme-protein vibrational couplings in cytochromes c provide a dynamic link that connects the heme-iron and the protein surface. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8896-900.
Levin, BD, Can, M, Bowman, SEJ, Bren, KL, Elliott, SJ. Methionine ligand lability in bacterial monoheme cytochromes c: An electrochemical study. J Phys Chem B. 2011 Oct 13;115(40):11718-26.
Chung, JK, Thielges, MC, Bowman, SEJ, Bren, KL, Fayer, MD. Temperature dependent equilibrium native to unfolded protein dynamics and properties observed with IR absorption and 2D IR vibrational echo experiments. J Am Chem Soc. 2011 May 4;133(17):6681-91.
Bowman, SEJ, Bren, KL. Variation and analysis of second sphere interactions and axial histidinate character in c-type cytochromes. Inorg Chem. 2010 Sep 6;49(17):7890-7
Bowman, SEJ, Bren, KL. The chemistry and biochemistry of heme c: Functional bases for covalent attachment. Nat Prod Rep. 2008 Dec;25(6):1118-30. doi: 10.1039/b717196j.
Kim, S, Chung, JK, Kwak, K, Bowman, SEJ, Bren, KL, Bagchi, B, Fayer, MD. Native and unfolded cytochrome c – Comparison of dynamics using 2D-IR vibrational echo spectroscopy. J Phys Chem B. 2008 Aug 14;112(32):10054-63.
Michel, LV, Ye, T, Bowman, SEJ, Levin, BD, Hahn, MA, Russell, BS, Elliott, SJ, Bren, KL. Heme attachment motif mobility tunes cytochrome c redox potential. Biochemistry. 2007 Oct 23;46(42):11753-60.
